aLTerGo,
I appreciate your comment. The Orion Db was one of the 4 SQL instances AppInsight was monitoring. I will return to work on Tuesday and add back one SQL instance at a time as you suggested.
As far as the computer environment goes, here is the break down:
VMWARE ESXi Host 5.1 with a NetApp backend(SAN Boot)
4 SQL Server 2008R2 Ent Edition SP2 running on VMDK disk, one for data, one for logs, one for temp and one for system DBs.
Jon