If the errors are happening consistently every 21 seconds (or so) perpetually without end, then it's very unlikely this is caused by Orion. If you can imagine an application template assigned to a node that contains say 5 WMI based component monitors that's configured to poll once every five minutes (default behavior), each component in the template will be polled at least once. There are retry mechanisms in place if the component fails but these retries occur with quick succession to the failure. Once all components fail the retry the component monitors are placed in a "Down" state in Orion. Their status icons are shown in "red" and alerts are raised (by default). No further polling occurs until 5 more minutes pass, when this process repeats itself. If you have applications in a "down" or "unknown" state assigned to the node in question, I recommend removing them or at least unmanaging them.
If these errors continue after removing or unmanaging all applications that are in a failed or unknown state, I suggest unmanaging the node itself for a period of time to see if the errors subside. If they do, please open a case with support. We will want to look through your diagnostics to determine what's causing these errors. If after unmanaging the node these errors continue to occur on the server, then it's a fairly safe bet they're not caused by Orion. To determine what device is querying the server you'll likely need to use something like WireShark and parse through the packet capture as I demonstrate here.